![]() ![]() The first onset of symptoms is usually between the ages of 50 and 65. The remaining 5–10% of the cases are familial-type ALS (FALS) due to their associated genetic dominant inheritance factor. The most common form is sporadic (90–95%) which has no obvious genetically inherited component. There are four other known MNDs: Primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), and pseudobulbar palsy.ĪLS is categorized in two forms. ALS is also known as Charcot disease in honor of the first person to describe the disease, Jean-Martin Charcot, and motor neuron disease (MND) as it is one of the five MNDs that affect motor neurons. The disease became well known in the United States when baseball player Lou Gehrig was diagnosed with the disease in 1939. Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that is, characterized by progressive loss of the upper and lower motor neurons (LMNs) at the spinal or bulbar level.ĪLS was first described in 1869 by French neurologist Jean-Martin Charcot. ![]()
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